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Previous Studies
The Retina Institute has recently participated in the following studies.  Enrollment is closed and/or the trial has been completed.

Acucela

A Phase 2b/3 Multicenter, Randomized, Double-Masked, Dose-Ranging Study Comparing the Efficacy and Safety of Emixustat Hydrochloride (ACU-4429) with Placebo for the Treatment of Geographic Atrophy Associated with Dry Age-Related Macular Degeneration


Allegro PVD


A Phase II, Randomized, Double-Masked, Placebo-Controlled Multicenter Clinical Trial Designed to Evaluate the Safety and Efficacy of Luminate in Inducing PVD in Subjects with Non-Proliferative Diabetic Retinopathy


AREDS2 for Dry AMD

Age-Related Eye Disease Study 2 (AREDS2): A mulit-center, randomized trial of lutein, zeaxanthin and Omega-3 long-chain polyunsaturated fatty acids (docosahexaenoic acid [DHA] and eicosapentaenoic acid [EPA] in age-related macular degeneration


CATT for AMD


Comparison of Age-related macular degeneration Treatments Trials (CATT)

CATT: Lucentis-Avastin Trial

Eylea for AMD

Short-Term Clinical Effects of EYLEA as a Predictor of Long-Term Results

HARBOR for Wet AMD

A Phase III, double-masked, multi-center, randomized, active treatment controlled study of the efficacy and safety of 0.5mg and 2.0mg ranibizumab administered monthly or on an as-needed basis (PRN) with a safety run-in of a single dose of 2.0mg ranibizumab in patients with subfoveal neovascular age-retlated macular degeneration

Lucentis for Histoplasmosis


Ranibizumab versus PDT for presumed ocular histoplasmosis

MUST for Uveitis

Multi-center Uveitis Steroid Treatment (MUST) trial

OPHTHOTECH

A phase 3 randomized, double-masked, controlled trial to establish the safety and efficacy of intravitreous administration of Fovista (anti-PDGF-B Pegylated Aptamer) administered in combination with Lucentis compared to Lucentis monotherapy in subjects with subfoveal neovascular Age-related Macular Degeneration



ORBIT

Ocriplasmin Research to Better Inform Treatment (ORBIT)


Ozurdex Study for RVO

Anatomic outcomes following Ozurdex injection using spectral domain optical coherence tomography (OCT)


PADDLE for RVO

Posterior vitreous detachment (PVD) Assessment During Dual RVO Lucentis Evaluations
(PADDLE study)


Sakura

A Phase III, Multinational, Multi-center, Randomized, Double-Masked, Study for the Treatment of Active, Non-Infectious Uveitis


View 1 for AMD


A randomized, double-masked active controlled Phase III study of the efficacy, safety and tolerability of repeated doses of intravitreal VEGF-trap in subjects with neovascular age-related macular degeneration

Protocol number: VGFT-OD-0605.01)



DRCR Network for Diabetic Retinopathy

The Diabetic Retinopathy Clinical Research Network (DRCR) conducts multiple clinical trials utilizing various treatments for diabetic retinopathy. Supported by National Institutes of Health (NIH).



DRCR - Protocol M


Effect of diabetes education during retinal ophthalmology visits on diabetes control



DRCR - Protocol R


  A Phase II evaluation of topical NSAIDS in eyes with non-central involved DME



DRCR - Protocol S


  Prompt PRP versus intravitreal ranibizumab with deferred PRP for proliferative diabetic retinopathy



DRCR - Protocol T


  A Comparative Effectiveness Study of Intravitreal Aflibercept, Bevacizumab and Ranibizumab for Diabetic Macular Edema (Comparing Eylea, Lucentis and Avastin for DME)


"Wet" Age-Related Macular Degeneration



Diabetic Retinopathy


Histoplasmosis
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